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Derek Thompson on AI, abundance, and human progress
Why can the United States government help make a vaccine in a year but not build a high-speed train in a reasonable timeframe? What if our biggest problems—affordable housing shortages, energy limits, and scientific slowdowns—aren’t inevitable, but chosen? This week, Reid and Aria sit down with Derek Thompson—staff writer at The Atlantic and host of the podcast Plain English—to explore how a scarcity mindset is holding American society back. They cover how AI can revolutionize scientific discovery; what Operation Warp Speed got right; and why real progress depends on bold policy, not just better technology. Plus, Reid joins Derek in the hotseat for some “Too Much, Too Little, or Just Right?”—a game co-created with ChatGPT to discuss ideas in Derek’s new best-selling book, Abundance. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ Select mentions: Abundance by Ezra Klein and Derek Thompson “The Anti-Social Century” Every Cure co-founder Dr. David Fajgenbaum Topics: 1:06 – Episode introduction 2:34 – What year would Derek choose to be born and why? 7:14 – What can AI do as a co-author that Ezra Klein can't, and what are Ezra's irreplaceable strengths? 9:08 – AI's impact on the future of work — what AI can and can't do — and what the enduring role of humans will be. 12:00 – The situation with current tariffs, and the potential fixes or silver linings. 14:28 – Operation Warp Speed and other examples of abundance in the U.S. and beyond. 19:39 – What specific government policies could effectively leverage AI to speed up the creation of abundance? 22:40 – Midroll 22:49 – Derek and Reid play a fun game based on Abundance: “Too much, too little, or just right?” 30:46 – What's needed to better incentivize scientific progress and foster innovation? 39:22 – How could society and our relationship with technology be reframed to combat the loneliness epidemic? 45:08 – Derek identifies specific policies that currently hinder abundance and suggests new ones that could promote it. 49:45 – Rapid-fire Questions Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.
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53:47
Reid riffs on Tobi’s memo, AI and play, and the tweet that cost trillions
After Tobi Lütke, the CEO of Shopify, put out a memo stating all his employees should be expected to use AI every day, Reid offers his thoughts on AI in the workplace. He also talks about the interplay between AI, social media, mis/disinformation, and the importance of shaping technology instead of restricting technology. Plus, Reid speculates on how AI can be just as groundbreaking in the world of play as it can be in the world of work. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/
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14:53
Demis Hassabis on AI, game theory, multimodality, and the nature of creativity
How can AI help us understand and master deeply complex systems—from the game Go, which has 10 to the power 170 possible positions a player could pursue, or proteins, which, on average, can fold in 10 to the power 300 possible ways? This week, Reid and Aria are joined by Demis Hassabis. Demis is a British artificial intelligence researcher, co-founder, and CEO of the AI company, DeepMind. Under his leadership, DeepMind developed Alpha Go, the first AI to defeat a human world champion in Go and later created AlphaFold, which solved the 50-year-old protein folding problem. He's considered one of the most influential figures in AI. Demis, Reid, and Aria discuss game theory, medicine, multimodality, and the nature of innovation and creativity. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ Select mentions: Hitchhiker's Guide to the Galaxy by Douglas Adams AlphaGo documentary: https://www.youtube.com/watch?v=WXuK6gekU1Y Nash equilibrium & US mathematician John Forbes Nash Homo Ludens by Johan Huizinga Veo 2, an advanced, AI-powered video creation platform from Google DeepMind The Culture series by Iain Banks Hartmut Neven, German-American computer scientist Topics: 3:11 - Hellos and intros 5:20 - Brute force vs. self-learning systems 8:24 - How a learning approach helped develop new AI systems 11:29 - AlphaGo’s Move 37 16:16 - What will the next Move 37 be? 19:42 - What makes an AI that can play the video game StarCraft impressive 22:32 - The importance of the act of play 26:24 - Data and synthetic data 28:33 - Midroll ad 28:39 - Is it important to have AI embedded in the world? 33:44 - The trade-off between thinking time and output quality 36:03 - Computer languages designed for AI 40:22 - The future of multimodality 43:27 - AI and geographic diversity 48:24 - AlphaFold and the future of medicine 51:18 - Rapid-fire Questions Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.
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56:40
Reid riffs on Signal, AI for cancer detection, and GPT-4o image generation
In the wake of Atlantic editor-in-chief Jeffrey Goldberg’s accidental inclusion in senior government officials’ Signal group chat discussing war plans, Reid weighs in on how the U.S. government should—and shouldn’t—use encrypted messaging apps. He and Aria also discuss AI-powered breakthroughs in cancer detection and medical diagnostics, along with NVIDIA’s newly announced Superchip and OpenAI’s latest image generation capabilities. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/
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14:47
Andrew Bosworth on AI, wearables, and mixed reality
The evolution of AI is changing the way we interact with the physical world, not just in how we use this technology, but also where and how we access it. In this episode, Reid and Aria sit down with Meta’s Chief Technology Officer, Andrew “Boz” Bosworth, who is pioneering wearables for the company. Boz’s journey in the tech sector has taken him from working on Microsoft Visio to founding Reality Labs, Meta’s AR and VR division. Now, he’s focused on the next frontier in mixed realities with his latest project, Orion, a pair of AR glasses. Boz offers an Orion demo and shares his vision for wearables as an equalizing technology that can unlock superpowers for every person. Plus, they check-in on the state of AI as it relates to open source software, safety, hyperscalers, and startups. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ Topics: 1:03 - Episode introduction 3:36 - How Boz’s farm upbringing influenced his career and perspective on the digital world 7:02 - How will wearables influence how we navigate the physical and digital worlds? 9:46 - Meta's AI philosophy 11:27 - Pi explains Norbert Wiener's construct of information theory 14:28 - What would it take to build AI world models? 15:09 - What are the most significant use cases for Orion? 19:01 - Can Orion accommodate monocular vision? 20:00 - Boz's response to Orion skeptics 22:29 - Boz gives predictions on our AI future 25:09 - What would it look like to have a compatible system of wearables? 27:30 - Unexpected discoveries from Orion testing 29:33 - What is Meta's focus in the AI space for the years to come? 30:48 - How do we ensure that AI innovation is used for good? 35:28 - Boz responds to Meta's changes in fact checking policy 37:11 - How will hyperscalers and start-ups flourish in the AI game? 40:06 - Boz shares his review on “The Wild Robot” 42:24 - Rapid-fire questions Select mentions: The Martian by Andy Weir Project Hail Mary by Andy Weir I Am a Strange Loop by Douglas Hofstadter J. C. R. Licklider, psychologist and computer scientist Douglas Engelbart, engineer and computer science pioneer Norbert Wiener, computer scientist and mathematician Yann LeCun, computer scientist and Chief AI Scientist at Meta Michael Abrash, Chief Scientist, Reality Labs, Meta Garry Kasparov, Russian chess grandmaster 4-H, a youth development program from the USDA The Biometric Information Privacy Act (BIPA) Qualified Business Income Deduction (QBI) Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Whether it's Inflection’s Pi, OpenAI’s ChatGPT or other AI tools, each episode will use AI to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.
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What if, in the future, everything breaks humanity's way? Possible is an award-winning, weekly podcast that sketches out the brightest version of the future—and what it will take to get there. Hosts Reid Hoffman and Aria Finger explore what’s possible with forward-thinking leaders, deep thinkers, and ambitious builders across many fields, such as technology, art, education and healthcare. These conversations center on the ways technology—and, in particular, AI—is shaping the future. In episodes, AI tools such as OpenAI’s GPT-4 and Inflection’s Pi are at work, offering informational asides, prompting guests, or demoing what they can do. Lastly, between guest episodes, Aria interviews her co-host Reid on his latest takes on what’s possible if we use technology—and our collective effort—effectively.

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