Science Friday

Today, November 8, 2024, marks Science Friday’s 33rd broadcast anniversary. One of the most beloved interviewees on Science Friday over the years was the late neurologist and author Dr. Oliver Sacks, who shared his insights into neuroscience, art, and what it means to be human. Recently, Sacks’ long-time collaborator Kate Edgar published a book of Dr. Sacks' letters. And earlier this fall, the New York Public Library announced its acquisition of Sacks’ entire archive.In this segment, Ira revisits a 2007 conversation with Oliver Sacks about his book Musicophilia. They talk about the way music and the brain interact, why music can sometimes remain in the brain long after other memories fade, and why a person with limited language abilities might still be able to sing unimpaired.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

In a Chinese study, donor CAR-T cells sent autoimmune diseases into remission. There’s hope that the therapy is scalable. And, scientists used decades of yellow-bellied marmot research to find a way to measure how adverse events affect wild animals’ survival.CAR-T Cell Therapies Show Promise For Autoimmune DiseasesFor decades, immunologists have explored CAR-T cell therapy as an effective tool to fight blood cancer. Increasingly, CAR-T cells are being explored as a potential silver bullet for treating autoimmune diseases, like lupus—which currently have no cure.Thus far, CAR-T cell therapy has largely used CRISPR-modified immune cells from a person to treat that person’s own diseases. But new research from China has made a huge step forward for this treatment: Researchers were successful in using donated CAR-T cells from one person to treat another person’s systemic sclerosis, an autoimmune condition that causes atypical growth of connective tissues.If donor CAR-T cell therapy does indeed work, as posited in this paper, it could mean the therapy is more scalable than it would be otherwise. Joining Ira to talk about this study and its potential impact is Daniel Baker, PhD student in the immunology lab of Dr. Carl June at the University of Pennsylvania.Measuring The Effects Of Early Life Adversity—In MarmotsIt’s well-established in psychology that if you experience trauma as a child, chances are it’ll impact your physical and mental health as an adult, and could even affect your economic status. In academic terms, this is called early childhood adversity. And psychologists have developed a scoring system for measuring the cumulative effect of adverse childhood experiences, which can include abuse and household dysfunction, and it can help predict health risks later in life.So we can specifically measure that in humans. But what about other animals? If you’ve adopted a dog that’s had a turbulent past, you know that that can result in reclusive or skittish behavior as an adult. But there hasn’t been a good way to measure it in wild animals.Well, a new study from UCLA, published in the journal Ecology Letters, establishes a similar index for wild animals, and it used decades of findings from a mammal: the yellow-bellied marmot. So how could it help conservation efforts for other animals?Ira Flatow talks with Xochitl Ortiz-Ross, a PhD student in ecology and evolutionary biology at UCLA, and one of the authors on that study.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Think back to the last time you went to the doctor’s office. Chances are, at the start of the visit, they took your temperature, pulse, and blood pressure—your “vitals.”But how did they take your blood pressure? The medical literature that describes safe blood pressure ranges is all based on readings taken with the patient sitting with feet flat on the floor, legs uncrossed, back supported, and the testing arm supported by a desk at mid-heart level. But if the blood pressure is measured with the person in a different position—say, perched on the edge of an exam table, legs dangling, and an arm hanging at the side—the readings given by a blood pressure monitor can be distorted. In a recent study published in the journal JAMA Internal Medicine, researchers found that arm position could account for as much as a 7mmHg difference in pressure readings. That difference could be enough to incorrectly classify some people as hypertensive.Dr. Tammy Brady, medical director of the Pediatric Hypertension Program at Johns Hopkins University, joins Ira to talk about the art of blood pressure measurement, how to better track your own blood pressure, how to find blood pressure monitors that have been properly validated, and the importance of advocating for yourself in medical settings.Transcript for this segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Have you ever been stuck in traffic and thought, if only this highway was a little wider so it could fit more cars? You aren’t alone.Many states have been expanding their highways. New York Governor Kathy Hochul recently announced a $1.3 billion project to expand one of the state’s highways for an estimated maximum six-minute travel savings. Other highway-widening projects are underway in Texas, California, and Maryland. In 2022, federal, state, and local governments in the US spent $127 billion on highway construction. Some departments of transportation say expanding highways is necessary to reduce congestion, especially in areas with growing populations, and to encourage economic development.But decades of research shows the opposite effects when highways are expanded—that travel times actually increase when more lanes are added. So how does this happen, and why do we keep expanding highways even though the research says it doesn’t work?Megan Kimble, journalist and author of City Limits: Infrastructure, Inequality, And The Future Of America’s Highways, joins Ira to break down the research behind highway widening and discuss how increasing funding for public transit could help make traffic better, and why some cities are deciding to remove their highways entirely.Read an excerpt from City Limits: Infrastructure, Inequality, And The Future Of America’s Highways.Transcript for this segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.