Science In Action

Sars CoV-2 has been with us for five years. In the first of a two-part special, Science in Action asks how well was science prepared for it? And are we any better prepared for the next one?Presenter: Roland Pease Producer: Alex Mansfield, with Debbie Kilbride Production co-ordinator: Jana Bennett-Holesworth

New insights into how our skin learns to tolerate and co-exist with bacteria on its surface show great potential for the development of simpler and less invasive vaccines. Stanford University’s Djenet Bousbaine has published two papers in Nature detailing the microbiological research and mouse vaccination experiments that could change the future of immunisation. The Sun is the hardest place in the Solar System to reach. But by the time the next edition of Science in Action is on air, NASA’s Parker Solar Probe will have swooped through the scorching corona layer of the Sun, re-emerged, and be readying itself to relay the details of magnetic fields and particle storms to the team. NASA Helioscience deputy manager, Nicky Rayl, reveals all about the mission and explains why the Parker Probe’s future looks bright. And a trip half a billion years back - and then some - to the dawn of complex life here on Earth. Microfossil hunter Shuhai Xiao, from Virginia Polytechnic Institute and State University, has been compiling a single statistical database to better understand evolution during the so-called ‘boring billion’, why subsequent changes on the planet triggered a new diversity of species to emerge, and how the interplay between biology and geology has paved the way for modern life as we know it.Presenter: Roland Pease Producer: Alex Mansfield Assistant Producer: William Hornbrook Production Coordinator: Jana Bennett-Holesworth(Image: Solar Activity Captured in H-Alpha Filter. Credit: Manuel Romano/NurPhoto via Getty Images.)

Heatwaves in the pacific ocean have had a devastating effect on seabird populations in the north eastern US. Julia Parrish and colleagues publish this week 4 million deaths of Alaskan common murres attributable to rising water temperatures during 2014-16, representing half the population. One idea is that the fish on which the birds feed swim at deeper depths to find cooler temperatures, taking them below the depth the birds can dive. Worse, the reduced population numbers have endured almost ten years later. Pre-eclampsia affects up to 5 percent of pregnancies across the world. It reduces blood flow through the placenta, endangering mother, and even hindering the development of the foetus. But a promising approach to a possible therapy is described by Kelsey Swingle and colleagues this week. Much like some covid vaccines, by using a sort of lipid nanoparticles to deliver mRNA directly to the placenta in pregnant mice has resulted in healthier outcomes by widening the placental capillaries, allowing blood to flow more normally.Angie Rasmussen updates Roland on some of the work reported at a conference in Japan this week, pointing more directly to the covid-19 pandemic originating from wild animals at the Wuhan market.And in two coordinated papers published in the journals Science and Nature this week, scientists have narrowed down the period of time in history that modern humans and neanderthals interbred, leading to nearly everyone outside of sub-Saharan Africa sharing up to 2% of European Neanderthal DNA today. The question remains as to whether it was a benefit or not to the resulting hybrid population. Co-author Manjusha Chintalapati and colleagues describe how not all the neanderthal crossovers went on to survive pre-history to count as our direct ancestors. But one period of time, around 47,000 years ago is stamped on (nearly) all of us.Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jana Bennett-Holesworth and Josie Hardy(Image: Group of common murres on a breeding colony in Alaska. Credit: Sarah Schoen/USGS)

Scientists have found that just one mutation in the current H5N1 virus in cattle can switch its preference from avian to human receptors. Jim Paulson and colleagues at the Scripps Institute did not use the whole virus to investigate this, but proteins from one of the Texas farm workers found to be infected. It suggests the bovine H5N1 virus has already evolved subtly. Meanwhile, Richard Webby of St. Jude Children's Research Hospital in Memphis helps us catch up on the latest known about the case of the Canadian teenager taken seriously ill a month ago with a different variant of avian H5N1. A debate has been rumbling this last year about the extent of ocean warming by, perhaps paradoxically, the reduction of particulate pollution from the fuel used by ships. The idea is that the small particles of sulphates and nitrates in the soot from funnels actually formed clouds over shipping lanes out at sea. This in turn sheltered the oceans to some extent from solar radiation, thus making latter decades of the 20th century seem cooler than they would have measured today. Hence, removing the particulate pollution from bunker fuel, mandated by the International Maritime Organisation a few years ago, may have contributed to the surge in ocean temperatures witnessed in the last two years. Daniele Visione, of Cornell, and colleagues have done the modelling and found that there has indeed been a noticeable effect. But earth’s oceans are certainly not as hot as Venus’ ones, if indeed such oceans ever existed. It has long been held that once upon a time our sunward neighbour might have possessed liquid water oceans, long since boiled off by runaway greenhouse effects of the atmosphere. But, breaking with science fiction visions of aliens paddling in temperate seas, Tereza Constantinou of Cambridge University has been looking at the gases coming out of the volcanos on Venus, and has concluded that the planet never had such surface water, basically because the rocks from which magma is made don’t billow steam when they boil today. Presented by Roland Pease Produced by Alex Mansfield with Debbie Kilbride Production Coordinator: Jana Bennett-Holesworth(Image: Bird Flu in Dairy Cows; Credit: The Washington Post via Getty Images)